Publications And Abstracts From The SardiNIA Project

Publications

Antonio Terracciano, Angelina R. Sutin, Robert R. McCrae, Barbara Deiana, Luigi Ferrucci, David Schlessinger, Manuela Uda, and Paul T. Costa, Jr.    Facets of personality linked to underweight and overweight   Psychosom Med. 2009 Jul;71(6):682-9. Epub 2009 May 4

Ilja M. Nolte, Chris Wallace, Stephen J. Newhouse, Daryl Waggott, Jingyuan Fu, Nicole Soranzo, Rhian Gwilliam, Panos Deloukas, Irina Savelieva, Dongling Zheng, Chrysoula Dalageorgou, Martin Farrall, Nilesh J. Samani, John Connell, Morris Brown, Anna Dominiczak, Mark Lathrop, Eleftheria Zeggini, Louise V. Wain, for the The Wellcome Trust Case Control Consortium, The DCCT/EDIC Research Group, Christopher Newton-Cheh, Mark Eijgelsheim, Kenneth Rice, Paul I. W. de Bakker, for the QTGEN consortium, Arne Pfeufer, Serena Sanna, Dan E. Arking, for the QTSCD consortium, Folkert W. Asselbergs, Tim D. Spector, Nicholas D. Carter, Steve Jeffery, Martin Tobin, Mark Caulfield, Harold Snieder, Andrew D. Paterson, Patricia B. Munroe, Yalda Jamshidi    Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies  PLoS One. 2009 Jul 9;4(7):e6138  

Kirill Tarasov, Serena Sanna, Angelo Scuteri, James Strait, Marco Orru, Afshin Parsa, Ping-I Lin, Andrea Maschio, Sandra Lai, Maria Piras, Marco Masala, Toshiko Tanaka, Wendy Post, Jeffrey O'Connell, David Schlessinger, Antonio Cao, Ramaiah Nagaraja, Braxton Mitchell, Goncalo Abecasis, Alan Shuldiner, Manuela Uda, Edward Lakatta, Samer Najjar    COL4A1 Is Associated With Arterial Stiffness by Genome-Wide Association Scan  Circulation: Cardiovascular Genetics. 2(2):151-158, April 2009

Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D Tobin, Murielle Bochud, Lachlan Coin, Samer S Najjar, Jing Hua Zhao, Simon C Heath, Susana Eyheramendy, Konstantinos Papadakis, Benjamin F Voight, Laura J Scott, Feng Zhang, Martin Farrall, Toshiko Tanaka, Chris Wallace, John C Chambers, Kay-Tee Khaw, Peter Nilsson, Pim van der Harst, Silvia Polidoro, Diederick E Grobbee, N Charlotte Onland-Moret, Michiel L Bots, Louise V Wain, Katherine S Elliott, Alexander Teumer, Jian'an Luan, Gavin Lucas, Johanna Kuusisto, Paul R Burton, David Hadley, Wendy L McArdle, Wellcome Trust Case Control Consortium, Morris Brown, Anna Dominiczak, Stephen J Newhouse, Nilesh J Samani, John Webster, Eleftheria Zeggini, Jacques S Beckmann, Sven Bergmann, Noha Lim, Kijoung Song, Peter Vollenweider, Gerard Waeber, Dawn M Waterworth, Xin Yuan, Leif Groop, Marju Orho-Melander, Alessandra Allione, Alessandra Di Gregorio, Simonetta Guarrera, Salvatore Panico, Fulvio Ricceri, Valeria Romanazzi, Carlotta Sacerdote, Paolo Vineis, Ines Barroso, Manjinder S Sandhu, Robert N Luben, Gabriel J Crawford, Pekka Jousilahti, Markus Perola, Michael Boehnke, Lori L Bonnycastle, Francis S Collins, Anne U Jackson, Karen L Mohlke, Heather M Stringham, Timo T Valle, Cristen J Willer, Richard N Bergman, Mario A Morken, Angela Doring, Christian Gieger, Thomas Illig, Thomas Meitinger, Elin Org, Arne Pfeufer, H Erich Wichmann, Sekar Kathiresan, Jaume Marrugat, Christopher J O'Donnell, Stephen M Schwartz, David S Siscovick, Isaac Subirana, Nelson B Freimer, Anna-Liisa Hartikainen, Mark I McCarthy, Paul F O'Reilly, Leena Peltonen, Anneli Pouta, Paul E de Jong, Harold Snieder, Wiek H van Gilst, Robert Clarke, Anuj Goel, Anders Hamsten, John F Peden, Udo Seedorf, Ann-Christine Syvanen, Giovanni Tognoni, Edward G Lakatta, Serena Sanna, Paul Scheet, David Schlessinger, Angelo Scuteri, Marcus Dorr, Florian Ernst, Stephan B Felix, Georg Homuth, Roberto Lorbeer, Thorsten Reffelmann, Rainer Rettig, Uwe Volker, Pilar Galan, Ivo G Gut, Serge Hercberg, G Mark Lathrop, Diana Zelenika, Panos Deloukas, Nicole Soranzo, Frances M Williams, Guangju Zhai, Veikko Salomaa, Markku Laakso, Roberto Elosua, Nita G Forouhi, Henry Volzke, Cuno S Uiterwaal, Yvonne T van der Schouw, Mattijs E Numans, Giuseppe Matullo, Gerjan Navis, Goran Berglund, Sheila A Bingham, Jaspal S Kooner, John M Connell, Stefania Bandinelli, Luigi Ferrucci, Hugh Watkins, Tim D Spector, Jaakko Tuomilehto, David Altshuler, David P Strachan, Maris Laan, Pierre Meneton, Nicholas J Wareham, Manuela Uda, Marjo-Riitta Jarvelin, Vincent Mooser, Olle Melander, Ruth JF Loos, Paul Elliott, Goncalo R Abecasis, Mark Caulfield & Patricia B Munroe   Genome-wide association study identifies eight loci associated with blood pressure   Nat Genet. 2009 May 10. [Epub ahead of print]

Serena Sanna, Fabio Busonero, Andrea Maschio, Patrick F. McArdle, Gianluca Usala, Mariano Dei, Sandra Lai, Antonella Mulas, Maria Grazia Piras, Lucia Perseu, Marco Masala, Mara Marongiu, Laura Crisponi, Silvia Naitza, Renzo Galanello, Goncalo R. Abecasis, Alan R. Shuldiner, David Schlessinger, Antonio Cao and Manuela Uda  Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia  Hum Mol Genet. 2009 May 6. [Epub ahead of print]

Antonio Terracciano, Sutin, Angelina R, McCrae, Robert R, Deiana, Barbara , Luigi Ferrucci, David Schlessinger, Manuela Uda, Paul T. Costa Jr   Facets of Personality Linked to Underweight and Overweight  Psychosom Med. 2009 May 4. [Epub ahead of print]

Cecilia M. Lindgren, Iris M. Heid, Joshua C. Randall, Claudia Lamina, Valgerdur Steinthorsdottir, Lu Qi, Elizabeth K. Speliotes, Gudmar Thorleifsson, Cristen J. Willer, Blanca M. Herrera, Anne U. Jackson, Noha Lim, Paul Scheet, Nicole Soranzo, Najaf Amin, Yurii S. Aulchenko, John C. Chambers, Alexander Drong, Jian'an Luan, Helen N. Lyon, Fernando Rivadeneira, Serena Sanna, Nicholas J. Timpson, M. Carola Zillikens, Jing Hua Zhao, Peter Almgren, Stefania Bandinelli, Amanda J. Bennett, Richard N. Bergman, Lori L. Bonnycastle, Suzannah J. Bumpstead, Stephen J. Chanock, Lynn Cherkas, Peter Chines, Lachlan Coin, Cyrus Cooper, Gabriel Crawford, Angela Doering, Anna Dominiczak, Alex S. F. Doney, Shah Ebrahim, Paul Elliott, Michael R. Erdos, Karol Estrada, Luigi Ferrucci, Guido Fischer, Nita G Forouhi, Christian Gieger, Harald Grallert, Christopher J. Groves, Scott Grundy, Candace Guiducci, David Hadley, Anders Hamsten, Aki S. Havulinna, Albert Hofman, Rolf Holle, John W. Holloway, Thomas Illig, Bo Isomaa, Leonie C. Jacobs, Karen Jameson, Pekka Jousilahti, Fredrik Karpe, Johanna Kuusisto, Jaana Laitinen, G. Mark Lathrop, Debbie A. Lawlor, Massimo Mangino, Wendy L. McArdle, Thomas Meitinger, Mario A. Morken, Andrew P. Morris, Patricia Munroe, Narisu Narisu, Anna Nordstrom, Peter Nordstrom, Ben A. Oostra, Colin N.A. Palmer, Felicity Payne, John F. Peden, Inga Prokopenko, Frida Renstrom, Aimo Ruokonen, Veikko Salomaa, Manjinder S. Sandhu, Laura J. Scott, Angelo Scuteri, Kaisa Silander, Kijoung Song, Xin Yuan, Heather M. Stringham, Amy J. Swift, Tiinamaija Tuomi, Manuela Uda, Peter Vollenweider, Gerard Waeber, Chris Wallace, G. Bragi Walters, Michael N. Weedon, The Wellcome Trust Case Control Consortium, Jacqueline C.M. Witteman, Cuilin Zhang, Weihua Zhang, Mark J. Caulfield, Francis S. Collins, George Davey Smith, Ian N. M. Day, Paul W. Franks, Andrew T. Hattersley, Frank B. Hu, Marjo-Riitta Jarvelin, Augustine Kong, Jaspal S. Kooner, Markku Laakso, Edward Lakatta, Vincent Mooser, Andrew D. Morris, Leena Peltonen, Nilesh J. Samani, Timothy D. Spector, David P. Strachan, Toshiko Tanaka, Jaakko Tuomilehto, Andre G. Uitterlinden , Cornelia M. Van Duijn, Nicholas J. Wareham, Hugh Watkins (for the PROCARDIS consortia), Dawn M. Waterworth, Michael Boehnke, Panos Deloukas, Leif Groop, David J. Hunter, Unnur Thorsteinsdottir, David Schlessinger, H-Erich Wichmann, Timothy M. Frayling, Goncalo R. Abecasis, Joel N. Hirschhorn, Ruth J.F. Loos, Kari Stefansson, Karen L. Mohlke, Ines Barroso & Mark I. McCarthy for the GIANT consortium.   Genome wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution  PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26   [ Download PDF File ]

Scuteri A, Najjar SS, Orru M, Albai G, Strait J, Tarasov KV, Piras MG, Cao A, Schlessinger D, Uda M, Lakatta EG.  Age- and gender-specific awareness, treatment, and control of cardiovascular risk factors and subclinical vascular lesions in a founder population: The SardiNIA Study.   Nutr Metab Cardiovasc Dis. 2009 Mar 25. [Epub ahead of print]

Arne Pfeufer, Serena Sanna, Dan E Arking, Martina Muller, Vesela Gateva, Christian Fuchsberger, Georg B Ehret, Marco Orru, Cristian Pattaro, Anna Kottgen, Siegfried Perz, Gianluca Usala, Maja Barbalic, Man Li, Benno Putz, Angelo Scuteri, Ronald J Prineas, Moritz F Sinner, Christian Gieger, Samer S Najjar, W H Linda Kao, Thomas W. Muhleisen, Mariano Dei, Christine Happle, Stefan Mohlenkamp, Laura Crisponi, Raimund Erbel, Karl-Heinz Jockel, Silvia Naitza, Gerhard Steinbeck, Fabio Marroni, Andrew A Hicks, Edward Lakatta, Bertram Muller-Myhsok, Peter P Pramstaller, H-Erich Wichmann, David Schlessinger, Eric Boerwinkle, Thomas Meitinger, Manuela Uda, Josef Coresh, Stefan Kaab, Goncalo R Abecasis & Aravinda Chakravarti   Common variants at ten loci modulate the QT interval duration in the QTSCD Study   Nat Genet. 2009 Apr;41(4):407-14. Epub 2009 Mar 22

Toshiko Tanaka, Paul Scheet, Betti Giusti, Stefania Bandinelli, Maria Grazia Piras, Gianluca Usala, Sandra Lai, Antonella Mulas, Anna Maria Corsi, Anna Vestrini, Francesco Sofi, Anna Maria Gori, Rosanna Abbate, Jack Guralnik, Andrew Singleton, Goncalo R. Abecasis, David Schlessinger, Manuela Uda and Luigi Ferrucci   Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations  Am J Hum Genet. 2009 Apr;84(4):477-82. Epub 2009 Mar 19

Antonio Terracciano, Lenuta Balaci, Jason Thayer, Matthew Scally, Sarah Kokinos, Luigi Ferrucci, Toshiko Tanaka, Alan B. Zonderman, Serena Sanna, Nazario Olla, Maria Antonietta Zuncheddu, Silvia Naitza, Fabio Busonero, Manuela Uda, David Schlessinger, Goncalo R. Abecasis, Paul T. Costa Jr    Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples  Am J Med Genet B Neuropsychiatr Genet. 2009 Feb 6. [Epub ahead of print]

Cristen J Willer, Elizabeth K Speliotes, Ruth J F Loos, Shengxu Li, Cecilia M Lindgren, Iris M Heid, Sonja I Berndt, Amanda L Elliott, Anne U Jackson, Claudia Lamina, Guillaume Lettre, Noha Lim, Helen N Lyon, Steven A McCarroll, Konstantinos Papadakis, Lu Qi, Joshua C Randal, Rosa Maria Roccasecca, Serena Sanna, Paul Scheet, Michael N Weedon, Eleanor Wheeler, Jing Hua Zhao, Leonie C Jacobs, Inga Prokopenko, Nicole Soranzo, Toshiko Tanaka, Nicholas J Timpson, Peter Almgren, Amanda Bennett, Richard N Bergman, Sheila A Bingham, Lori L Bonnycastle, Morris Brown, Noel P Burtt, Peter Chines, Lachlan Coin, Francis S Collins, John M Connell, Cyrus Cooper, George Davey Smith, Elaine M Dennison, Parimal Deodhar, Paul Elliott, Michael R Erdos, Karol Estrada, David M Evans, Lauren Gianniny, Christian Gieger, Christopher J Gillson, Candace Guiducci, Rachel Hackett, David Hadley, Alistair S Hall, Aki S Havulinna, Johannes Hebebrand, Albert Hofman, Bo Isomaa, Kevin B Jacobs, Toby Johnson, Pekka Jousilahti, Zorica Jovanovic, Kay-Tee Khaw, Peter Kraft, Mikko Kuokkanen, Johanna Kuusisto, Jaana Laitinen, Edward G Lakatta, Jian'an Luan, Robert N Luben, Massimo Mangino, Wendy L McArdle, Thomas Meitinger, Antonella Mulas, Patricia B Munroe, Narisu Narisu, Andrew R Ness, Kate Northstone, Stephen O'Rahilly, Carolin Purmann, Matthew G Rees, Martin Ridderstrale, Susan M Ring, Fernando Rivadeneira, Aimo Ruokonen, Manjinder S Sandhu, Jouko Saramies, Laura J Scott, Angelo Scuteri, Kaisa Silander, Matthew A Sims, Kijoung Song, Jonathan Stephens, Suzanne Stevens, Heather M Stringham, Y C Loraine Tung, Timo T Valle, Cornelia M Van Duijn, Karani S Vimaleswaran, Peter Vollenweider, Gerard Waeber, Chris Wallace, Richard M Watanabe, Dawn M Waterworth, Nicholas Watkins, Jacqueline C M Witteman, Eleftheria Zeggini, Guangju Zhai, M Carola Zillikens, David Altshuler, Mark J Caulfield, Stephen J Chanock, I Sadaf Farooqi, Luigi Ferrucci, Jack M Guralnik, Andrew T Hattersley, Frank B Hu, Marjo-Riitta Jarvelin, Markku Laakso, Vincent Mooser, Ken K Ong, Willem H Ouwehand, Veikko Salomaa, Nilesh J Samani, Timothy D Spector, Tiinamaija Tuomi, Jaakko Tuomilehto, Manuela Uda, Andre G Uitterlinden, Nicholas J Wareham, Panagiotis Deloukas, Timothy M Frayling, Leif C Groop, Richard B Hayes, David J Hunter, Karen L Mohlke, Leena Peltonen, David Schlessinger, David P Strachan, H-Erich Wichmann, Mark I McCarthy, Michael Boehnke, Ines Barroso, Goncalo R Abecasis & Joel N Hirschhorn for the GIANT Consortium    Six new loci associated with body mass index highlight a neuronal influence on body weight regulation  Nat Genet. 2008 Dec 14. [Epub ahead of print]

Inga Prokopenko, Claudia Langenberg, Jose C Florez, Richa Saxena, Nicole Soranzo, Gudmar Thorleifsson, Ruth J F Loos, Alisa K Manning, Anne U Jackson, Yurii Aulchenko, Simon C Potter, Michael R Erdos, Serena Sanna, Jouke-Jan Hottenga, Eleanor Wheeler, Marika Kaakinen, Valeriya Lyssenko, Wei-Min Chen, Kourosh Ahmadi, Jacques S Beckmann, Richard N Bergman, Murielle Bochud, Lori L Bonnycastle, Thomas A Buchanan, Antonio Cao, Alessandra Cervino, Lachlan Coin, Francis S Collins, Laura Crisponi, Eco J C de Geus, Abbas Dehghan, Panos Deloukas, Alex S F Doney, Paul Elliott, Nelson Freimer, Vesela Gateva, Christian Herder, Albert Hofman, Thomas E Hughes, Sarah Hunt, Thomas Illig, Michael Inouye, Bo Isomaa, Toby Johnson, Augustine Kong, Maria Krestyaninova, Johanna Kuusisto, Markku Laakso, Noha Lim, Ulf Lindblad, Cecilia M Lindgren, Owen T McCann, Karen L Mohlke, Andrew D Morris, Silvia Naitza, Marco Orru, Colin N A Palmer, Anneli Pouta, Joshua Randall, Wolfgang Rathmann, Jouko Saramies, Paul Scheet, Laura J Scott, Angelo Scuteri, Stephen Sharp, Eric Sijbrands, Jan H Smit, Kijoung Song, Valgerdur Steinthorsdottir, Heather M Stringham, Tiinamaija Tuomi, Jaakko Tuomilehto, Andre G Uitterlinden, Benjamin F Voight, Dawn Waterworth, H-Erich Wichmann, Gonneke Willemsen, Jacqueline C M Witteman, Xin Yuan, Jing Hua Zhao, Eleftheria Zeggini, David Schlessinger, Manjinder Sandhu, Dorret I Boomsma, Manuela Uda, Tim D Spector, Brenda WJH Penninx, David Altshuler, Peter Vollenweider, Marjo Riitta Jarvelin, Edward Lakatta, Gerard Waeber, Caroline S Fox, Leena Peltonen, Leif C Groop, Vincent Mooser, L Adrienne Cupples, Unnur Thorsteinsdottir, Michael Boehnke, Ines Barroso, Cornelia Van Duijn, Josee Dupuis, Richard M Watanabe, Kari Stefansson, Mark I McCarthy, Nicholas J Wareham, James B Meigs & Goncalo R Abecasis    Variants in MTNR1B influence fasting glucose levels.  Nat Genet. 2008 Dec 7. [Epub ahead of print]

Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, Eric E Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka, Benjamin F Voight, Lori L Bonnycastle, Anne U Jackson, Gabriel Crawford, Aarti Surti, Candace Guiducci, Noel P Burtt, Sarah Parish, Robert Clarke, Diana Zelenika, Kari A Kubalanza, Mario A Morken, Laura J Scott, Heather M Stringham, Pilar Galan, Amy J Swift, Johanna Kuusisto, Richard N Bergman, Jouko Sundvall, Markku Laakso, Luigi Ferrucci, Paul Scheet, Serena Sanna, Manuela Uda, Qiong Yang, Kathryn L Lunetta, Josee Dupuis, Paul I W de Bakker, Christopher J O'Donnell, John C Chambers, Jaspal S Kooner, Serge Hercberg, Pierre Meneton, Edward G Lakatta, Angelo Scuteri, David Schlessinger, Jaakko Tuomilehto, Francis S Collins, Leif Groop, David Altshuler, Rory Collins, G Mark Lathrop, Olle Melander, Veikko Salomaa, Leena Peltonen, Marju Orho-Melander, Jose M Ordovas, Michael Boehnke, Goncalo R Abecasis, Karen L Mohlke & L Adrienne Cupples    Common variants at 30 loci contribute to polygenic dyslipidemia.   Nat Genet. 2008 Dec 7. [Epub ahead of print]

A Terracciano, S Sanna, M Uda, B Deiana, G Usala, F Busonero, A Maschio, M Scally, N Patriciu, W-M Chen, M A Distel, E P Slagboom, D I Boomsma, S Villafuerte, E liwerska, M Burmeister, N Amin, A C J W Janssens, C M van Duijn, D Schlessinger, G R Abecasis and P T Costa Jr    Genome-wide association scan for five major dimensions of personality.  Mol Psychiatry. 2008 Oct 28. [Epub ahead of print]

Guillaume Lettre, Vijay G. Sankaran, Marcos Andre C. Bezerra, Aderson S. Arau jo, Manuela Uda, Serena Sanna, Antonio Cao, David Schlessinger, Fernando F. Costa, Joel N. Hirschhorn,and Stuart H. Orkin   DNA polymorphisms at the BCL11A, HBS1L-MYB, and {beta}-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease  Proc Natl Acad Sci U S A. 2008 Jul 30. [Epub ahead of print]   [ Download PDF File ]

Wei-Min Chen, Michael R. Erdos, Anne U. Jackson, Richa Saxena, Serena Sanna, Kristi D. Silver, Nicholas J. Timpson, Torben Hansen, Marco Orru, Maria Grazia Piras, Lori L. Bonnycastle, Cristen J. Willer, Valeriya Lyssenko, Haiqing Shen, Johanna Kuusisto, Shah Ebrahim, Natascia Sestu, William L. Duren, Maria Cristina Spada, Heather M. Stringham, Laura J. Scott, Nazario Olla, Amy J. Swift, Samer Najjar, Braxton D. Mitchell, Debbie A. Lawlor, George Davey Smith, Yoav Ben-Shlomo, Gitte Andersen, Knut Borch-Johnsen, Torben Jorgensen, Jouko Saramies, Timo T. Valle, Thomas A. Buchanan, Alan R. Shuldiner, Edward Lakatta, Richard N. Bergman, Manuela Uda, Jaakko Tuomilehto, Oluf Pedersen, Antonio Cao, Leif Groop, Karen L. Mohlke, Markku Laakso, David Schlessinger, Francis S. Collins, David Altshuler, Goncalo R. Abecasis, Michael Boehnke, Angelo Scuteri, and Richard M. Watanabe   Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels   J Clin Invest. 2008 Jun 2. [Epub ahead of print]   [ Download PDF File ]

Lisette Arnaud-Lopez, Gianluca Usala, Graziano Ceresini, Braxton D. Mitchell, Maria Grazia Pilia, Maria Grazia Piras, Natascia Sestu, Andrea Maschio, Fabio Busonero, Giuseppe Albai, Mariano Dei, Sandra Lai, Antonella Mulas, Laura Crisponi, Toshiko Tanaka, Stefania Bandinelli, Jack M. Guralnik, Angela Loi, Lenuta Balaci, Gabriella Sole, Alessia Prinzis, Stefano Mariotti, Alan R. Shuldiner, Antonio Cao, David Schlessinger, Manuela Uda, Goncalo R. Abecasis, Ramaiah Nagaraja, Serena Sanna, Silvia Naitza   Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function  American journal of human genetics doi:10.1016/j.ajhg.2008.04.019

Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M Freathy, Antony P Attwood, Jacques S Beckmann, Sonja I Berndt, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Sven Bergmann, Amanda J Bennett, Sheila A Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex S F Doney, Katherine S Elliott, Paul Elliott, David M Evans, I Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J Groves, Rhian Gwilliam, David Hadley, Alistair S Hall, Andrew T Hattersley, Johannes Hebebrand, Iris M Heid, KORA, Blanca Herrera, Anke Hinney, Sarah E Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer D M Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N Luben, Massimo Mangino, Jonathan Marchini, Wendy L McArdle, Ralph McGinnis, David Meyre, Patricia B Munroe, Andrew D Morris, Andrew R Ness, Matthew J Neville, Alexandra C Nica, Ken K Ong, Stephen O'Rahilly, Katharine R Owen, Colin N A Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study, Joshua C Randall, Nigel W Rayner, Susan M Ring, Manjinder S Sandhu, Andre Scherag, Matthew A Sims, Kijoung Song, Nicole Soranzo, Elizabeth K Speliotes, Diabetes Genetics Initiative, Holly E Syddall, Sarah A Teichmann, Nicholas J Timpson, Jonathan H Tobias, Manuela Uda, The SardiNIA Study, Carla I Ganz Vogel, Chris Wallace, Dawn M Waterworth, Michael N Weedon, The Wellcome Trust Case Control Consortium, Cristen J Willer, FUSION, Vicki L Wraight, Xin Yuan, Eleftheria Zeggini, Joel N Hirschhorn, David P Strachan, Willem H Ouwehand, Mark J Caulfield, Nilesh J Samani, Timothy M Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham & Ines Barroso Common variants near MC4R are associated with fat mass, weight and risk of obesity Nat Genet. 2008 May 4. [Epub ahead of print]

Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, Serena Sanna, Susana Eyheramendy, Benjamin F Voight, Johannah L Butler, Candace Guiducci, Thomas Illig, Rachel Hackett, Iris M Heid, Kevin B Jacobs, Valeriya Lyssenko, Manuela Uda, The Diabetes Genetics Initiative, FUSION, KORA, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial, The Nurses' Health Study, SardiNIA, Michael Boehnke, Stephen J Chanock, Leif C Groop, Frank B Hu, Bo Isomaa, Peter Kraft, Leena Peltonen, Veikko Salomaa, David Schlessinger, David J Hunter, Richard B Hayes, Goncalo R Abecasis, H-Erich Wichmann, Karen L Mohlke & Joel N Hirschhorn Identification of ten loci associated with height highlights new biological pathways in human growth Nat Genet. 2008 May;40(5):584-91. Epub 2008 Apr 6

Serena Sanna, Anne U Jackson, Ramaiah Nagaraja, Cristen J Willer, Wei-Min Chen, Lori L Bonnycastle, Haiqing Shen, Nicholas Timpson, Guillaume Lettre, Gianluca Usala, Peter S Chines, Heather M Stringham, Laura J Scott, Mariano Dei, Sandra Lai, Giuseppe Albai, Laura Crisponi, Silvia Naitza, Kimberly F Doheny, Elizabeth W Pugh, Yoav Ben-Shlomo, Shah Ebrahim, Debbie A Lawlor, Richard N Bergman, Richard M Watanabe, Manuela Uda, Jaakko Tuomilehto, Josef Coresh, Joel N Hirschhorn, Alan R Shuldiner, David Schlessinger, Francis S Collins, George Davey Smith, Eric Boerwinkle, Antonio Cao, Michael Boehnke, Goncalo R Abecasis & Karen L Mohlke Common variants in the GDF5-UQCC region are associated with variation in human height
Nature Genetics 40, 198 - 203 (2008)

Cristen J Willer, Serena Sanna, Anne U Jackson, Angelo Scuteri, Lori L Bonnycastle, Robert Clarke, Simon C Heath, Nicholas J Timpson, Samer S Najjar, Heather M Stringham, James Strait, William L Duren, Andrea Maschio, Fabio Busonero, Antonella Mulas, Giuseppe Albai, Amy J Swift, Mario A Morken, Narisu Narisu, Derrick Bennett, Sarah Parish, Haiqing Shen, Pilar Galan, Pierre Meneton, Serge Hercberg, Diana Zelenika, Wei-Min Chen, Yun Li, Laura J Scott, Paul A Scheet, Jouko Sundvall, Richard M Watanabe, Ramaiah Nagaraja, Shah Ebrahim, Debbie A Lawlor, Yoav Ben-Shlomo, George Davey-Smith, Alan R Shuldiner, Rory Collins, Richard N Bergman, Manuela Uda, Jaakko Tuomilehto, Antonio Cao, Francis S Collins, Edward Lakatta, G Mark Lathrop, Michael Boehnke, David Schlessinger, Karen L Mohlke & Goncalo R Abecasis Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nature Genetics 40, 161 - 169 (2008)

Siguang Li, Serena Sanna, Andrea Maschio, Fabio Busonero, Gianluca Usala, Antonella Mulas, Sandra Lai, Mariano Dei, Marco Orru, Giuseppe Albai, Stefania Bandinelli, David Schlessinger, Edward Lakatta, Angelo Scuteri, Samer S. Najjar, Jack Guralnik, Silvia Naitza, Laura Crisponi, Antonio Cao, Gonçalo Abecasis, Luigi Ferrucci, Manuela Uda, Wei-Min Chen, Ramaiah Nagaraja The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. PLoS Genetics, e194.eor doi:10.1371/journal.pgen.0030194.eor   [ Download PDF File ]

Angelo Scuteri, Serena Sanna, Wei-Min Chen, Manuela Uda, Giuseppe Albai, James Strait, Samer S. Najjar, Ramaiah Nagarajah, Marco Orru, Gianluca Usala, Mariano Dei, Sandra Lai, Andrea Maschio, Fabio Busonero, Antonella Mulas, George B Ehret, Ashley A Fink, Alan Weder, Richard Cooper, Pilar Galan, Aravinda Chakravarti, David Schlessinger, Antonio Cao, Edward Lakatta, Goncalo Abecasis Genome Wide Association Scan shows Genetic Variants in the FTO gene are Associated with Obesity Related Traits PLoS Genet. 2007 Jul 20;3(7):e115 [Epub ahead of print]   [ Download PDF File ]

Paul T. Costa, Jr, Antonio Terracciano, Manuela Uda, Loredana Vacca, Cinzia Mameli, Giuseppe Pilia, Alan B. Zonderman, Edward Lakatta, David Schlessinger, Robert R. McCrae Personality Traits in Sardinia: Testing Founder Population Effects on Trait Means and Variances Behavior Genetics 2007 Mar;37(2):376-87. Epub 2006 Sep 14

Chen, W.M., Abecasis, G.R. Estimating the power of variance component linkage analysis in large pedigrees. Genet. Epidemiol. 2006 Sep;30(6):471-84

The program and discussion were prerequisite for the analysis of the highly inter-related cohort assembled for the Project.

Giuseppe Pilia, Weimin Chen, Angelo Scuteri, Marco Orru, Giuseppe Albai, Mariano Dei, Sandra Lai, Gianluca Usala, Monica Lai, Paola Loi, Cinzia Mameli, Loredana Vacca, Manila Deiana, Nazario Olla, Marco Masala, Antonio Cao, Samer S Najjar, Antonio Terraciano, Timur Nedorezov, Alexei A Sharov, Alan B Zonderman, Goncalo Abecasis, Paul Costa, Edward Lakatta, David Schlessinger  Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians  PLoS Genet. 2006 Aug 25;2(8)    [ Download PDF File ]

This is the first extensive report on the extent of contribution of genetic and environmental factors to a range of traits in the population.

Abstracts

S. Sanna, A.U. Jackson, G. Usala, C.J. Willer, M. Dei, L.L. Bonnycastle, S. Lai, Y. Li, M. Uda, M.R. Erdos, H. Shen, A. Shuldiner, A. Cao, R.M. Bergam, D. Schlessinger, F.S. Collins, M. Boehnke, G.R. Abecasis, R. Nagaraja, K.L. Mohlke  Genome-wide association scan for height in 6,671 individuals from Finland and Sardinia.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

C.J. Willer, A. Scuteri, L.L. Bonnycastle, S. Sanna, A.U. Jackson, A. Maschio, W.L. Duren, F. Busonero, R. Pruim, Diabetes Genetics Initiative, R.M. Watanabe, S.S. Najjar, L.J. Scott, M. Uda, J. Tuomilehto, G.R. Abecasis, F.S. Collins, D. Schlessinger, K.L. Mohlke, E.G. Lakatta  Genome-wide association scan for HDL cholesterol, LDL cholesterol and triglyceride levels in 9,000 individuals.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

S. Li, S. Sanna, M. Dei, S. Lai, G. Usala, A. Maschio, F. Busonero, A. Mulas, M. Orrù, G. Albai, S. Bandinelli, D. Schlessinger, A. Scuteri, S. Najjar, A. Cao, G. Abecasis, L. Ferrucci, M. Uda, WM. Chen, R. Nagaraja  The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

M. Uda, S. Sanna, W.-M. Chen, G. Albai, G. Usala, A. Maschio, F. Busonero, A. Mulas, M. Dei, S. Lai, A. Scuteri, M. Orru', S. Naitza, L. Crisponi, M. Masala, E. Lakatta, P. Costa, G. R. Abecasis, D. Schlessinger, A. Cao  First results of a genome-wide association using jointly 10k and 500k Affymetrix chips in a Sardinian cohort  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

S. Naitza, L. Balaci, M. C. Spada, N. Olla, G. Sole, F. Anedda, M. A. Zuncheddu, A. Maschio, C. Caria, S. Sanna, S. Pilia, S. Sanna, L. Crisponi, G. Malerba, P. F. Pignatti, D. Schlessinger, A. Cao, M. Uda  Mutation and functional analysis of the IRAK-M gene in Sardinian asthmatic patients  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

W. M. Chen, A. U. Jackson, A. Scuteri, M. R. Erdos, M. Uda, W. L. Duren, S. Sanna, H. M. Stringham, A. Mulas, H. Shen, L. J. Scott, S. Najjar, A. R. Shuldiner, J. Tuomilehto, E. Lakatta, R. N. Bergman, D. Schlessinger, M. Boehnke, G. R. Abecasis, R. M. Watanabe  Genome-wide association scans in cohorts from Sardinia and Finland identify a locus for fasting glucose levels  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Oral Presentation]

Scuteri A , Orru M , Najjar SS , Uda M , Cao A , Lakatta EG Age-associated trends in the prevalence of the metabolic syndrome and its components: effects of gender. The ProgeNIA Study. 1st European Association for Cardiovascular Prevention and Rehabilitation (EACPR) Meeting - Athens (Greece), May 11-13, 2006 [poster]

Scuteri A , Orru M , Najjar SS , Uda M , Cao A , Lakatta EG. Prevalenza della sindrome metabolica e delle sue componenti con l' invecchiamento: effetti del sesso. Il ProgeNIA Study. XXIII Congresso Nazionale della Societa Italiana dell'Ipertensione Arteriosa - Roma (Italy), September 29- October 2, 2006 [oral communication]