Publications And Abstracts From The SardiNIA Project

Publications

Ruth J F Loos, Cecilia M Lindgren, Shengxu Li, Eleanor Wheeler, Jing Hua Zhao, Inga Prokopenko, Michael Inouye, Rachel M Freathy, Antony P Attwood, Jacques S Beckmann, Sonja I Berndt, The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Sven Bergmann, Amanda J Bennett, Sheila A Bingham, Murielle Bochud, Morris Brown, Stéphane Cauchi, John M Connell, Cyrus Cooper, George Davey Smith, Ian Day, Christian Dina, Subhajyoti De, Emmanouil T Dermitzakis, Alex S F Doney, Katherine S Elliott, Paul Elliott, David M Evans, I Sadaf Farooqi, Philippe Froguel, Jilur Ghori, Christopher J Groves, Rhian Gwilliam, David Hadley, Alistair S Hall, Andrew T Hattersley, Johannes Hebebrand, Iris M Heid, KORA, Blanca Herrera, Anke Hinney, Sarah E Hunt, Marjo-Riitta Jarvelin, Toby Johnson, Jennifer D M Jolley, Fredrik Karpe, Andrew Keniry, Kay-Tee Khaw, Robert N Luben, Massimo Mangino, Jonathan Marchini, Wendy L McArdle, Ralph McGinnis, David Meyre, Patricia B Munroe, Andrew D Morris, Andrew R Ness, Matthew J Neville, Alexandra C Nica, Ken K Ong, Stephen O'Rahilly, Katharine R Owen, Colin N A Palmer, Konstantinos Papadakis, Simon Potter, Anneli Pouta, Lu Qi, Nurses' Health Study, Joshua C Randall, Nigel W Rayner, Susan M Ring, Manjinder S Sandhu, Andre Scherag, Matthew A Sims, Kijoung Song, Nicole Soranzo, Elizabeth K Speliotes, Diabetes Genetics Initiative, Holly E Syddall, Sarah A Teichmann, Nicholas J Timpson, Jonathan H Tobias, Manuela Uda, The SardiNIA Study, Carla I Ganz Vogel, Chris Wallace, Dawn M Waterworth, Michael N Weedon, The Wellcome Trust Case Control Consortium, Cristen J Willer, FUSION, Vicki L Wraight, Xin Yuan, Eleftheria Zeggini, Joel N Hirschhorn, David P Strachan, Willem H Ouwehand, Mark J Caulfield, Nilesh J Samani, Timothy M Frayling, Peter Vollenweider, Gerard Waeber, Vincent Mooser, Panos Deloukas, Mark I McCarthy, Nicholas J Wareham & Ines Barroso Common variants near MC4R are associated with fat mass, weight and risk of obesity Nat Genet. 2008 May 4. [Epub ahead of print]

Guillaume Lettre, Anne U Jackson, Christian Gieger, Fredrick R Schumacher, Sonja I Berndt, Serena Sanna, Susana Eyheramendy, Benjamin F Voight, Johannah L Butler, Candace Guiducci, Thomas Illig, Rachel Hackett, Iris M Heid, Kevin B Jacobs, Valeriya Lyssenko, Manuela Uda, The Diabetes Genetics Initiative, FUSION, KORA, The Prostate, Lung Colorectal and Ovarian Cancer Screening Trial, The Nurses' Health Study, SardiNIA, Michael Boehnke, Stephen J Chanock, Leif C Groop, Frank B Hu, Bo Isomaa, Peter Kraft, Leena Peltonen, Veikko Salomaa, David Schlessinger, David J Hunter, Richard B Hayes, Goncalo R Abecasis, H-Erich Wichmann, Karen L Mohlke & Joel N Hirschhorn Identification of ten loci associated with height highlights new biological pathways in human growth Nat Genet. 2008 May;40(5):584-91. Epub 2008 Apr 6

Serena Sanna, Anne U Jackson, Ramaiah Nagaraja, Cristen J Willer, Wei-Min Chen, Lori L Bonnycastle, Haiqing Shen, Nicholas Timpson, Guillaume Lettre, Gianluca Usala, Peter S Chines, Heather M Stringham, Laura J Scott, Mariano Dei, Sandra Lai, Giuseppe Albai, Laura Crisponi, Silvia Naitza, Kimberly F Doheny, Elizabeth W Pugh, Yoav Ben-Shlomo, Shah Ebrahim, Debbie A Lawlor, Richard N Bergman, Richard M Watanabe, Manuela Uda, Jaakko Tuomilehto, Josef Coresh, Joel N Hirschhorn, Alan R Shuldiner, David Schlessinger, Francis S Collins, George Davey Smith, Eric Boerwinkle, Antonio Cao, Michael Boehnke, Goncalo R Abecasis & Karen L Mohlke Common variants in the GDF5-UQCC region are associated with variation in human height
Nature Genetics 40, 198 - 203 (2008)

Cristen J Willer, Serena Sanna, Anne U Jackson, Angelo Scuteri, Lori L Bonnycastle, Robert Clarke, Simon C Heath, Nicholas J Timpson, Samer S Najjar, Heather M Stringham, James Strait, William L Duren, Andrea Maschio, Fabio Busonero, Antonella Mulas, Giuseppe Albai, Amy J Swift, Mario A Morken, Narisu Narisu, Derrick Bennett, Sarah Parish, Haiqing Shen, Pilar Galan, Pierre Meneton, Serge Hercberg, Diana Zelenika, Wei-Min Chen, Yun Li, Laura J Scott, Paul A Scheet, Jouko Sundvall, Richard M Watanabe, Ramaiah Nagaraja, Shah Ebrahim, Debbie A Lawlor, Yoav Ben-Shlomo, George Davey-Smith, Alan R Shuldiner, Rory Collins, Richard N Bergman, Manuela Uda, Jaakko Tuomilehto, Antonio Cao, Francis S Collins, Edward Lakatta, G Mark Lathrop, Michael Boehnke, David Schlessinger, Karen L Mohlke & Goncalo R Abecasis Newly identified loci that influence lipid concentrations and risk of coronary artery disease Nature Genetics 40, 161 - 169 (2008)

Siguang Li, Serena Sanna, Andrea Maschio, Fabio Busonero, Gianluca Usala, Antonella Mulas, Sandra Lai, Mariano Dei, Marco Orru, Giuseppe Albai, Stefania Bandinelli, David Schlessinger, Edward Lakatta, Angelo Scuteri, Samer S. Najjar, Jack Guralnik, Silvia Naitza, Laura Crisponi, Antonio Cao, Gonçalo Abecasis, Luigi Ferrucci, Manuela Uda, Wei-Min Chen, Ramaiah Nagaraja The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. PLoS Genetics, e194.eor doi:10.1371/journal.pgen.0030194.eor   [ Download PDF File ]

Angelo Scuteri, Serena Sanna, Wei-Min Chen, Manuela Uda, Giuseppe Albai, James Strait, Samer S. Najjar, Ramaiah Nagarajah, Marco Orru, Gianluca Usala, Mariano Dei, Sandra Lai, Andrea Maschio, Fabio Busonero, Antonella Mulas, George B Ehret, Ashley A Fink, Alan Weder, Richard Cooper, Pilar Galan, Aravinda Chakravarti, David Schlessinger, Antonio Cao, Edward Lakatta, Goncalo Abecasis Genome Wide Association Scan shows Genetic Variants in the FTO gene are Associated with Obesity Related Traits PLoS Genet. 2007 Jul 20;3(7):e115 [Epub ahead of print]   [ Download PDF File ]

Paul T. Costa, Jr, Antonio Terracciano, Manuela Uda, Loredana Vacca, Cinzia Mameli, Giuseppe Pilia, Alan B. Zonderman, Edward Lakatta, David Schlessinger, Robert R. McCrae Personality Traits in Sardinia: Testing Founder Population Effects on Trait Means and Variances Behavior Genetics 2007 Mar;37(2):376-87. Epub 2006 Sep 14

Chen, W.M., Abecasis, G.R. Estimating the power of variance component linkage analysis in large pedigrees. Genet. Epidemiol. 2006 Sep;30(6):471-84

The program and discussion were prerequisite for the analysis of the highly inter-related cohort assembled for the Project.

Giuseppe Pilia, Weimin Chen, Angelo Scuteri, Marco Orru, Giuseppe Albai, Mariano Dei, Sandra Lai, Gianluca Usala, Monica Lai, Paola Loi, Cinzia Mameli, Loredana Vacca, Manila Deiana, Nazario Olla, Marco Masala, Antonio Cao, Samer S Najjar, Antonio Terraciano, Timur Nedorezov, Alexei A Sharov, Alan B Zonderman, Goncalo Abecasis, Paul Costa, Edward Lakatta, David Schlessinger  Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians  PLoS Genet. 2006 Aug 25;2(8)    [ Download PDF File ]

This is the first extensive report on the extent of contribution of genetic and environmental factors to a range of traits in the population.

Abstracts

S. Sanna, A.U. Jackson, G. Usala, C.J. Willer, M. Dei, L.L. Bonnycastle, S. Lai, Y. Li, M. Uda, M.R. Erdos, H. Shen, A. Shuldiner, A. Cao, R.M. Bergam, D. Schlessinger, F.S. Collins, M. Boehnke, G.R. Abecasis, R. Nagaraja, K.L. Mohlke  Genome-wide association scan for height in 6,671 individuals from Finland and Sardinia.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

C.J. Willer, A. Scuteri, L.L. Bonnycastle, S. Sanna, A.U. Jackson, A. Maschio, W.L. Duren, F. Busonero, R. Pruim, Diabetes Genetics Initiative, R.M. Watanabe, S.S. Najjar, L.J. Scott, M. Uda, J. Tuomilehto, G.R. Abecasis, F.S. Collins, D. Schlessinger, K.L. Mohlke, E.G. Lakatta  Genome-wide association scan for HDL cholesterol, LDL cholesterol and triglyceride levels in 9,000 individuals.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

S. Li, S. Sanna, M. Dei, S. Lai, G. Usala, A. Maschio, F. Busonero, A. Mulas, M. Orrù, G. Albai, S. Bandinelli, D. Schlessinger, A. Scuteri, S. Najjar, A. Cao, G. Abecasis, L. Ferrucci, M. Uda, WM. Chen, R. Nagaraja  The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts.  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

M. Uda, S. Sanna, W.-M. Chen, G. Albai, G. Usala, A. Maschio, F. Busonero, A. Mulas, M. Dei, S. Lai, A. Scuteri, M. Orru', S. Naitza, L. Crisponi, M. Masala, E. Lakatta, P. Costa, G. R. Abecasis, D. Schlessinger, A. Cao  First results of a genome-wide association using jointly 10k and 500k Affymetrix chips in a Sardinian cohort  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

S. Naitza, L. Balaci, M. C. Spada, N. Olla, G. Sole, F. Anedda, M. A. Zuncheddu, A. Maschio, C. Caria, S. Sanna, S. Pilia, S. Sanna, L. Crisponi, G. Malerba, P. F. Pignatti, D. Schlessinger, A. Cao, M. Uda  Mutation and functional analysis of the IRAK-M gene in Sardinian asthmatic patients  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Poster]

W. M. Chen, A. U. Jackson, A. Scuteri, M. R. Erdos, M. Uda, W. L. Duren, S. Sanna, H. M. Stringham, A. Mulas, H. Shen, L. J. Scott, S. Najjar, A. R. Shuldiner, J. Tuomilehto, E. Lakatta, R. N. Bergman, D. Schlessinger, M. Boehnke, G. R. Abecasis, R. M. Watanabe  Genome-wide association scans in cohorts from Sardinia and Finland identify a locus for fasting glucose levels  The American Society of Human Genetics 57th Annual Meeting at San Diego, California. October 23-27, 2007 [Oral Presentation]

Scuteri A , Orru M , Najjar SS , Uda M , Cao A , Lakatta EG Age-associated trends in the prevalence of the metabolic syndrome and its components: effects of gender. The ProgeNIA Study. 1st European Association for Cardiovascular Prevention and Rehabilitation (EACPR) Meeting - Athens (Greece), May 11-13, 2006 [poster]

Scuteri A , Orru M , Najjar SS , Uda M , Cao A , Lakatta EG. Prevalenza della sindrome metabolica e delle sue componenti con l' invecchiamento: effetti del sesso. Il ProgeNIA Study. XXIII Congresso Nazionale della Societa Italiana dell'Ipertensione Arteriosa - Roma (Italy), September 29- October 2, 2006 [oral communication]